PUBLICATIONS AND NEWS
Here you will find all of our scientific research, posters and latest news. Keep up to date as we continue to develop the BioVolume platform and publish research adding to the oncology communities understanding of pre-clinical efficacy.
Comparing Variability in Measurement of Subcutaneous Tumors in Mice Using 3D Thermal Imaging and Calipers
1/4/23, 11:44 AM
Download our publication in JAALAS Comparative Medicine investigating how variability can be reduced in the measurement of Subcutaneous Tumors in Mice when using 3D Thermal Imaging
In Silico Modeling Demonstrates that User Variability During Tumor Measurement Can Affect In Vivo Efficacy Outcomes
12/6/22, 11:44 AM
User measurement bias is a source of variation in preclinical studies. We investigated if variability could impact outcomes, using false negative result rate when comparing treated and control groups.
PRE-PRINT RESEARCH PUBLICATIONS
Pre-print paper: Trends in Subcutaneous Tumour Height and Impact on Measurement Accuracy
10/4/22, 9:32 AM
We show measuring tumour height is essential in calculating accurate tumour volumes, improving accuracy, reproducibility and ability to correctly identify drug effect.
Reducing inter-operator variability when measuring subcutaneous tumours in mice
10/11/21, 9:58 AM
Our preprint publication analysing operator variability of BioVolume vs callipers, and impact on drug efficacy assessment in over 5,000 repeats across 238 studies.
Modelling the cost impact of creating greater preclinical reproducibility through digitization
11/14/22, 11:58 AM
Poster presented at AALAS 2022 exploring how digitizing preclinical processes within efficacy testing, has the potential to reduce the cost of drug development by $39 million.
Optimising Measurement Of Subcutaneous Rodent Leg Tumours
3/25/22, 1:51 PM
Our work with HZDR found measurement variability of rodent leg tumours can be decreased by inoculating tumour high up in the shoulder, and by using BioVolume instead of callipers.
Improving reproducibility through data traceability with St. Jude Children's Research Hospital
3/9/21, 9:27 AM
Data traceability and its contribution to study reproducibility a poster in partnership with St. Jude Children's Research Hospital
Measurement of subcutaneous tumor height achieves greater volumetric accuracy
11/14/22, 11:58 AM
Poster presented at AALAS 2022 highlighting the need to capture tumor height for more accurate volumes.
Using calibrated photographic images and thermal data to investigate trends in tumour conditions
10/11/21, 10:34 AM
A poster analysing how structured image and thermal data can be used to identify trends in tumour condition in both the days leading up to, and the days following the point of ulceration.
Reducing inter-operator variability poster with GNF
11/16/20, 9:58 AM
A poster publication in partnership with GNF exploring how BioVolume can reduce inter-operator variability in measuring subcutaneous tumours
Re-evaluating historic preclinical endpoints with BioVolume
6/24/22, 8:10 AM
With previous experimental methods built around the limitations of calliper acquisition, we provide a method to align historical endpoints with the BioVolume platform.
A comparison of tumour volume accuracy taken with Callipers and BioVolume when compared to excised tumour weights
10/11/21, 10:19 AM
A poster exploring how using a BioVolume captured height measurement offers an average volume 8 times closer to the excised weight measurements than callipers.
WHITE PAPERS AND INSIGHT
Whitepaper: Modelling the economic impact of improving preclinical reproducibility with BioVolume
12/16/22, 11:00 AM
This report demonstrates how adopting BioVolume could save up to $38m in the drug development cycle, utilising the economic model created by Paul et al in their 2010 analysis.